项目介绍

2025年4月16日

Are you ready to work on the old dream of curing deafness?

We offer one exciting research position in the Mesoscale Chemical Systems group.

Join our highly motivated and multidisciplinary team working on revolutionary methods for needle-free injections!

Hearing loss affects millions of people, but delivering medication deep into the inner ear remains a major challenge. Therefore, this project, funded by the ZonMw Open Competition grant, will address this problem with a precise and gentle solution.

We plan on developing novel methods, including needle-free injections for the accurately delivering drugs. By combining microfluidics, human tissue models, and patient involvement, the project aims to make treatments for hearing loss safer, more effective, and more widely accessible. The project will be executed in collaboration with researchers from Radboudumc, Medizinische Hochschule Hannover, and the University of Twente. We will perform fundamental research and clinical collaboration with support from the TechMed Centre and MESA+ Institute.

This project will use state-of-the-art technology developed in the BuBble Gun Project.

Together with collaborating experts from medical centers, commercial partners and spin-off companies, this project will contribute to developing a novel technology to provide personalized and effective medical and cosmetic treatments.

More general info:

New-technology-for-drug-delivery-in-hearing-loss

What will you be doing and learning?

The two PhD candidates working on this project will have complementary expertise in medical biology and bioengineering, and will be based at Radboudumc and UTwente, respectively. Close collaboration between the PhD students will foster the synergy between all project partners. The PhD candidates will frequently move between our partnering institutions (1.5-2h travel) to fully integrate their expertise and advance the research. Using video calling, the unique expertise in cochlea biophysics from the Hannover team is easily integrated.

The main objective of the work is to find how can we (repeatedly) deliver drugs to the cochlea in a safe and sustainable manner?

Moreover, we will:

o   Characterize the mechanical and biological properties of the RWM.

o   Develop numerical and in-vitro models to investigate drug delivery.

o   Employ microfluidics technology to identify safe and minimally invasive methods for intra-cochlear drug delivery.

Experimental plan: To develop reliable numerical/computational methods to study liquid-tissue dynamic properties. Here the team will ensure reproducible conditions to obtain parameters of tissue response at spatiotemporal scales not achieved before, with complimentary techniques.

We will establish finite element (FE) models of the human cochlea in (not limited to ABAQUS, ANSYS, etc.), using cochlear geometry obtained from literature.

The model will be refined to implement the specific properties of the different RWM models, employing Particle methods (e.g. Episim and UTwente’s MercuryDPM) to simulate the dynamics of discrete cells and Newtonian and non-Newtonian fluid-structure interaction models to assess how the intracochlear fluid (perilymph) influences RWM deformation.

We will also develop in-vitro models that better resemble the intricate cochlear architecture to investigate drug delivery. Moreover, we will employ microscopy techniques to describe tissue integrity and drug pathways at the molecular level. This will help us understand how both the drugs and drug solutions behave during paracellular drug delivery.

Your profile

• You are a curious and enthusiastic researcher ready to learn about various aspects ranging from fluid dynamics, material properties and ear anatomy.
• You have experience in any of the following fields: bioengineering, physics, computational models. We could discuss potential reorientation.
• You have a creative mindset, excellent analytical and communication skills with a good team spirit for interdisciplinary and internationally oriented environment.

Our offer

• A full-time position for four years, with a qualifier in the first year, and the flexibility to work (partially) from home.
• Your salary and associated conditions are in accordance with the collective labour agreement for Dutch universities (CAO-NU).
• For the PhD positions, you will receive a gross monthly salary ranging from € 2.901,-  (first year) to € 3.707,- (fourth year).
• A minimum of 232 leave hours in case of full-time employment based on a formal workweek of 38 hours. A full-time employment in practice means 40 hours a week, therefore resulting in 96 extra leave hours on an annual basis.
• Free access to sports facilities on campus.
• A family-friendly institution that offers parental leave (both paid and unpaid).
• You will have a training program as part of the Twente Graduate School where you and your supervisors will determine a plan for a suitable education.

Information and application

To apply, please submit your application by the button below, this should include:

• A cover letter (maximum 1 page A4) emphasizing your specific interest, qualifications, and motivations to apply for this position.
• A Curriculum Vitae, including a list of all courses attended and grades obtained, and, if applicable, a list of publications and references.
• Email addresses of at least two references who are willing to send a letter of recommendation on your behalf.
• An IELTS-test, Internet TOEFL test (TOEFL-iBT), or a Cambridge CAE-C (CPE). Applicants with a non-Dutch qualification and who have not had secondary and tertiary education in English can only be admitted with an IELTS-test showing a total band score of at least 6.5, internet. TOEFL test (TOEFL-iBT) showing a score of at least 90, or a Cambridge CAE-C (CPE).

An interview with a scientific presentation will be part of the inerview proces.