项目介绍

2026年7月3日

How do cells decide what gets in and what stays out? Biology seemed to have a simple answer: molecular transport depends on structure. Yet two remarkable cellular gateways have broken that rule. Join us to unravel how these unique protein-based filters achieve extraordinary selectivity—and uncover the fundamental principles that govern transport into some of the cell’s most important compartments. In the Molecular Biophysics group of the Zernike Institute for Advanced Materials, a globally recognized research institute within the University of Groningen for nanoscience and nanotechnology, we are seeking a highly motivated PhD candidate to tackle this fundamental question using cutting-edge super-resolution microscopy. This fully funded 4-year PhD position is available in the group of Prof. Rifka Vlijm.

What are you going to do?

The goal of this PhD project is to use, among others, STED super-resolution microscopy to visualize how transport is occurring in the cell to unravel the role of unstructured proteins as filters in cellular transport processes. The work will involve mammalian and yeast cell culture, advanced fluorescence live-cell microscopy, development of automated experimental workflows, image and data analysis, and scientific programming. During this 4-year project you will work closely with the other team members within this NWO funded consortium “Holey trap”, in the groups of Prof. Patrick Onck (project lead, Zernike Institute), Rifka Vlijm (Zernike Institute), Liesbeth Veenhoff (UMCG) and Cees Dekker (TU Delft), promoting an interdisciplinary approach to this challenge. The work is done in the Zernike Institute for Advanced Materials that is part of the Faculty of Science and Engineering.

Faculty of Science and EngineeringApply no later than: 25 July 202623:59 Dutch local time€3.059 – €3.881

Who are you?

We are looking for an enthusiastic and talented PhD candidate with:

·      A MSc degree in biophysics. Depending on the specialization, a MSc in molecular biology, biotechnology/bioengineering, physics (optics) or equivalent certification also qualify (please provide transcripts during your application).

·      A strong experimental background in microscopy, molecular biophysics/biology, or cell biology.

·      Experience with python programming and cell culture will be seen as a strong asset.

·      Capacity to think analytically and creatively.

·      High motivation in pursuing academic research.

·      Ability to work in an international team in a streamlined and professional way.

·      An integrative and cooperative personality with excellent communicative and social skills

·      Fluent proficiency in English – written and oral (please provide a proof of English language proficiency during your application).

Please clearly explain in your motivation letter why you are applying for this position and how your previous education and work experience align with the PhD project. Additionally, upload a minimum of two letters of recommendation relevant to the proposed work.

What can you expect from us?

• In accordance with the collective labor agreement for Dutch universities, we offer a salary of at least € 3.059 up to a maximum of € 3.881 (promovendus) gross per month for a full-time employment contract.
• 232 vacation hours per year, based on a 38-hour workweek (1.0 FTE). You can also work more or fewer hours in exchange for more or fewer free hours. For example, with a 40-hour workweek, you save 96 extra free hours, and with a 36-hour workweek, you lose 96 hours.
• End-of-year bonus of 8.3% and 8% holiday allowance.
• Extensive opportunities for personal and professional development.
• Promovendus: 1 year + 3 year

Where will you be working?

At the University of Groningen (UG), researchers from all fields of academia and technology are working on academic challenges and societal questions. Lecturers prepare their students for meaningful careers within or outside the academic world. Interdisciplinary research and teaching, sharing of knowledge, collaboration with businesses, government institutions, and societal organizations are aspects that are of the utmost importance to this European top university. The UG aims to be an open academic community with an inclusive and safe working climate that invites you to add your value.

The Faculty of Science and Engineering (FSE) provides teaching and research across a wide range of disciplines, from physics and biology to artificial intelligence, mechanical engineering, and pharmacy. In close collaboration with partners from industry, healthcare, and society, we contribute to the urgent challenges of our time, such as energy, sustainability, digitization, and medical technology. Our community is open and informal, with more than 7,000 students, 1,000 PhD students, and 1,400 staff members from all over the world. If you would like to learn more about the Faculty of Science and Engineering, visit rug.nl/fse. 

At the University of Groningen (UG), researchers from all fields of academia and technology are working on academic challenges and societal questions. Lecturers prepare their students for meaningful careers within or outside the academic world. Interdisciplinary research and teaching, sharing of knowledge, collaboration with businesses, government institutions, and societal organizations are aspects that are of the utmost importance to this European top university. The UG aims to be an open academic community with an inclusive and safe working climate that invites you to add your value.

The Faculty of Science and Engineering (FSE) provides teaching and research across a wide range of disciplines, from physics and biology to artificial intelligence, mechanical engineering, and pharmacy. In close collaboration with partners from industry, healthcare, and society, we contribute to the urgent challenges of our time, such as energy, sustainability, digitization, and medical technology. Our community is open and informal, with more than 7,000 students, 1,000 PhD students, and 1,400 staff members from all over the world. If you would like to learn more about the Faculty of Science and Engineering, visit rug.nl/fse.