项目介绍

2025年2月2日

Our lab combines experimentation in a.o. C. elegans as an animal model system with computational modeling to address fundamental questions in morphogenesis and development. We study the roles of force generation and mechanofeedback systems in shaping tissues during development. As part of the Bioengineering Faculty at KU Leuven, we contribute to a strong record of combining advanced modeling with experimentation to study living systems, with applications in both fundamental and applied research. We are part of an active and collaborative research community in Flanders, with four C. elegans labs in Leuven. Our lab offers a supportive and inspiring environment for interdisciplinary research and learning, and is located on a beautiful campus next to the historic centre of Leuven.

Website van de eenheid

Project

We are recruiting a PhD student with a background in experimental biology to work on self-organization in multicellular systems.

In our lab, we use C. elegans embryogenesis as a model to understand how cells can achieve near-invariant positioning as they form a complex multicellular system. In this project, you will use quantitative microscopy to probe the embryo and perturb the system, for example with temporal and spatial resolution using optogenetics. Our research aims to identify new relevant molecular actors involved in positioning, and to explore the role of mechanics, cellular stiffness, adhesion and cell polarization. The research in our group is multidisciplinary, meaning that experiments and imaging are supported by efforts to expand the molecular biology toolbox, enhance image processing and computational modeling. We will also extend our work to studying early embryogenesis in higher animals.

The PhD project can include perturbing cortical tension optogenetically during morphogenesis, evaluating mechanosensing in the embryo, or performing an innovative reverse genetic screen for robust cellular positioning. As a member of our team, the successful candidate will have the opportunity to work with state-of-the-art microscopy and computational tools and collaborate with experts internationally.

Profile

• Talented and enthusiastic molecular and cellular biology researcher. Master degree in biology, biotechnology, bioengineering, or similar. Good grasp of molecular and developmental biology as well as genetics with an interest in interdisciplinary work.
• Study results should show high aptitude and research interest
• Good communicative skills and a collaborative attitude
• Advanced command of English is required (knowledge of Dutch is not required)

Offer

• A high-profile project with great scientific potential 

• Excellent scientific environment in top-ranked university, using state-of-the-art technology and methodology.
• Living in the beautiful medieval university town Leuven, a lively city situated in the heart of 
Europe, 20 km from Brussels 

• Good remuneration and benefits
• Funding is guaranteed (4 years for PhD student), but the successful candidate will be encouraged to apply for fellowships, such as those by the Flemish funding agency (FWO).
• Applicants should submit a detailed CV and a cover letter expressing your motivation and interest in the position.
• Contact details for two referees who can provide academic references (no letters).

Interested?

For more information please don’t hesitate to contact Rob Jelier: rob.jelier@kuleuven.beYou can apply for this job no later than March 03, 2025 via the online application tool

KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.

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