项目介绍

2022年9月28日

Molecular cancer biologists at Duke University seek to understand the complex regulatory mechanisms that govern mammalian cell growth and differentiation, discern how these mechanisms are perturbed in malignant cells, and how our knowledge of these regulatory mechanisms might lead to improved anti-cancer therapy. This research covers the boundaries of disciplines such as pharmacology, biochemistry, molecular biology, genetics, genomics, and cell biology, which together are leading to greater understanding of the basic mechanisms underlying growth regulation and their alterations during tumor progression and metastasis.

The Program in Molecular Cancer Biology (MCB) includes faculty from multiple participating departments and centers across Duke University and Duke School of Medicine. Program scientists are actively engaged in dissecting the regulatory networks that control the processes of growth and development at the cellular and molecular levels, and identifying the defects that lead to oncogenic transformation. The approaches used by the investigators include genomics, genetics, cell biology, molecular biology and protein biochemistry. An ultimate goal is to identify novel candidates for therapeutic intervention in the treatment of cancer. Graduate training in this program is greatly enhanced by the collaborative interactions among investigators across the University and the School of Medicine.