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Project title: RNA biomarkers of ischemic stroke subtypes and outcomes
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Stroke is a common disorder and stroke is the most common cause of acquired disability in adults. Ischemic stroke is caused by a blood clot. This can occur in different ways, which means that there are different etiological subtypes. There is currently very little knowledge regarding blood-based biomarker profiles for the different subtypes and there is a great need to better understand the underlying mechanisms, as this has implications for choice and efficacy of treatment. RNA expressed in peripheral blood cells and extracellular RNA (exRNA, i.e. in extracellular vesicles which can drive from distant tissues including brain) are emerging as precision biomarkers in other diseases. Therefore, one of the main aims of this PhD project is to identify subtype-specific RNA profiles to gain novel mechanistic insights for ischemic stroke. There is also a need to better understand molecular mechanisms involved in recovery after ischemic stroke. While some individuals recover fully, others are left with persistent and severe disabilities. Therefore, the second main aim of this PhD project is to identify RNA biomarkers that improve our ability to predict post-stroke outcomes, and increase our understanding of biological pathways underlying stroke recovery. Finally, the student will characterize the source of identified exRNAs. This part of the project will focus on brain-derived extracellular vesicles and will also include human cell culture experiments (e.g. culturing neurons and astrocytes).
This research project integrates clinical and experimental studies. The PhD student will practice a range of bioinformatics methods for statistical analysis and visualization of RNA-sequencing data and also gain hands-on experience in various molecular biology techniques. In the long run, knowledge gained from the proposed PhD project may contribute to better prevention, diagnostic and therapeutic strategies for stroke. The main and co-supervisors have complementary competencies, which means that we can offer very good guidance in this translation project and we can offer a stimulating and interactive environment.
Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.
To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.
A person meets the general entry requirements for third-cycle studies if he or she: 1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad
A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies
In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for: – specific knowledge and skills within the subject area and related research fields – experience of scientific theory and relevant research methodology – scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Documented experience in handling and analyzing large genetic and clinical databases, working with UNIX/Linux as well as established programming languages (e.g. R) are meritorious, as is experience using web-based bioinformatics tools and public databases within relevant areas. Further, experience within the field of extracellular vesicles and/or stroke as well of cell culture and molecular biology is desirable. Applicants need to have a very good ability to express themselves scientifically in English in speech and writing. Great emphasis will be placed on personal qualities such as good communication and collaboration skills, and a motivated and driven personality with genuine interest in research within biomarker and stroke.
After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.
Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Laboratory Medicine. Extent: 100%. First day of employment: as agreed.
Salaries for doctoral students are regulated in a local agreement at the University.
For further information regarding the position
For more information about the project please contact the principal supervisor, Tara Stanne, Institute of Biomedicine, e-mail: email@example.com
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How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
You must include the following, in pdf format
Diploma and transcripts showing that you meet with the general entry requirement
Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.