卡罗林斯卡医学院

Receptor Pharmacology

项目介绍

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

In the division “Receptor Biology & Signaling” headed by Prof Gunnar Schulte, G protein-coupled receptors (GPCRs) and particularly Class F receptors are in focus. The work aims to better understand how ligands interact with Class F receptors, how conformational changes are established to activate the receptors and – consequently – how those initiate interaction and selective activation of intracellular signaling components. Class F receptor structure and functional selectivity of Class F receptors towards heterotrimeric G proteins or other pathways are analyzed with the hope to exploit the novel knowledge therapeutically.

For recent publications please see:

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G*, Xu F*. Cell Res. 2021 Jul 8. doi: 10.1038/s41422-021-00525-6. PMID: 34239071 (*shared correspondence)

Residue 6.43 defines receptor function in class F GPCRs. Turku A, Schihada H, Kozielewicz P, Bowin CF, Schulte GNat Commun. 2021 Jun 24;12(1):3919. doi: 10.1038/s41467-021-24004-z. PMID: 34168128

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, Schulte GNat Commun. 2019 Feb 8;10(1):667. doi: 10.1038/s41467-019-08630-2. PMID: 30737406

The doctoral student project and the duties of the doctoral student

The doctoral project is aimed to better understand the molecular underpinnings of Frizzled activation both on a structural and functional level. The work is embedded in the current activities of the group with the breadth of methodology characteristic for the laboratory ranging from in silico approaches, molecular biology, biophysical methodology (BRET), protein chemistry and structural biology. In parallel to the research education in the group as well as in collaboration with national and international collaborators, the doctoral student will be involved in laboratory and administrative duties. Furthermore, opportunities for hands-on Masters student supervision and undergraduate teaching at the department will be offered.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirementYou meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The candidate should have a theoretical and practical background in biochemistry, biomedicine, pharmacology, or structural biology (experience with transmembrane proteins and CryoEM would be advantageous). We expect a successful applicant to have basic knowledge in GPCR pharmacology and protein chemistry and it would be desirable if experience in protein purification exists. It is necessary for the motivated student to thrive in an interdisciplinary environment and a dynamic and international research team. It is required that the student has extensive practical lab experience exemplified by successful Bachelor or Masters projects or other e. g. extracurricular laboratory activities.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

项目概览

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截止日期 2021-12-05
卡罗林斯卡医学院

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卡罗林斯卡医学院,是瑞典著名的医学院,也是世界医学排名前十的医学院之一。
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