查尔姆斯理工大学

Precision Medicine for Osteoarthritis

项目介绍

Information about the project
Osteoarthritis (OA) remains a major challenge due to the lack of available therapies. In the Biofunctinal Nanomedicine Lab we study disease mechanisms and develop immunomodulating materials for inflammatory diseases. By defining pathological mechanism we can delicately fine-tune a materials’ properties towards their intended purposes, tissue environments, and physical properties to regulate immune responses and achieve improved health outcomes. We now offer a PhD position in a project that aims to understand underlying disease mechanisms involving glycoprotein modifications to develop novel nanotherapeutic strategies for osteoarthritis (OA). 

In this interdisciplinary project we use multiple methods and models, spanning from binding studies and proteomics to cellular studies and animal models to elucidate underlying disease mechanisms active in OA. With this information we will find novel biomarkers and design targeting nanomaterials as novel therapeutic options for OA.

Key parts of the work will be:
– Cellular and immunological studies using immortalized cells, primary cells, and patient material
– Immunological method development
– Animal studies
– Treatment efficacy studies
– Data analysis

Information about the Chemical Biology division
How do biomolecules work in cellular environments? In the Chemical Biology division, we combine and develop protein engineering, synthetic chemistry, and state-of-the-art biophysical methods (spectroscopy, live cell imaging and nanotechnology) to address cutting-edge questions in biology to meet medical challenges related to human health. Our joint expertise is strategic and spans from molecular biophysics of single molecules to cell and organism biology. The division is placed in the Department of Biology and Biological Engineering at Chalmers University of Technology, in Sweden.

Major responsibilities
Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research verbally and in writing, both in Swedish and in English. The position may also include teaching on Chalmers’ undergraduate level or performing other academic duties to some extent.

Contract terms
Full-time temporary employment. The position is limited to a maximum of four years of full-time studies.

Qualifications
To qualify as a PhD student, you must have a master’s level degree corresponding to at least 240 higher education credits in Nanomedicine, Molecular Biology, Biomedicine or equivalent (or be in the process of completing a Master’s degree) with focus on medicine and drug delivery. Experience with immunology is meritious. Due to the interdisciplinary nature of the work you need to have excellent collaboration skills. It is also important that you have a very good capability of communicating scientific results in English, both orally and in writing. If Swedish is not your native language, Chalmers offers Swedish courses.

We offerChalmers offers a cultivating and inspiring working environment in the coastal city of Gothenburg
Read more about working at Chalmers and our benefits for employees.

Chalmers aims to actively improve our gender balance. We work broadly with equality projects, for example the GENIE Initiative on gender equality for excellence. Equality and diversity are substantial foundations in all activities at Chalmers.

Application procedure
The application should be marked with Ref 20210531 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV:(Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter:(Please name the document as: Personal letter, Family name, Ref. number)
1-3 pages where you:
• Introduce yourself
• Describe your previous experience of relevance for the position (e.g. education, thesis work and, if applicable, any other research activities)
• Describe your future goals and future research focus

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, e.g. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

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截止日期 2021-12-17
查尔姆斯理工大学

院校简介

查尔姆斯理工大学是一所以工程技术、自然科学和建筑学的教育与研究为主旨的欧洲顶尖理工院校。
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联系方式

电话: +46 (0)31-772 10 00

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