项目介绍

2026年6月29日

The University of Gothenburg tackles society’s challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

At the Institute of Neuroscience and Physiology, at the Sahlgrenska Academy, we conduct research and education covering a wide range of knowledge areas. The institute comprises five different departments: Clinical Neuroscience, Health and Rehabilitation, Pharmacology, Physiology and Psychiatry and Neurochemistry.

The Institute of Neuroscience and Physiology, invites applications for a postdoctoral researcher employment at the Department of Psychiatry and Neurochemistry.

The Neurochemistry laboratory at the Department of Psychiatry and Neurochemistry conducts neurochemical medical research targeted to understand the pathophysiology of Alzheimer’s disease and other brain disorders. An important goal is to identify protein changes linked to the pathophysiology of human diseases, known as biomarkers, which can be valuable to explore disease mechanisms, for diagnosis and to monitor treatment effects in man.

The Department of Psychiatry and Neurochemistry is seeking a postdoctoral researcher to conduct research on the identification and development of biomarkers for neurodegenerative diseases in cerebrospinal fluid and blood using LC–MS-based proteomics and isotope dilution mass spectrometry. 

Subject area

Neurochemistry, with focus on Proteomics and Biomarkers

Subject area description

Neurodegenerative diseases, particularly dementias, are becoming increasingly prevalent as the population ages. Current cognitive tests used in dementia diagnostics are often too blunt to detect mild cognitive impairment or to differentiate between various neurodegenerative disorders. While cerebrospinal fluid (CSF), and more recently blood-based, biomarkers exist for Alzheimer’s disease (AD) and are routinely used in diagnostics, such markers are still lacking for other conditions. Thus, we need new markers to improve our understanding of disease mechanisms and to facilitate early and reliable diagnosis. 

Job assignments 

The assignements involves performing mass spectrometry-based proteomic analyses of cerebrospinal fluid and plasma using TMT-based quantification and data-independent acquisition (DIA) in cohorts of patients with various neurodegenerative disorders, including Alzheimer’s disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Parkinsonian disorders. The aim is to identify protein alterations associated with the underlying pathological processes of these diseases. 

The employment also includes the development of targeted analytical methods for selected candidate biomarkers using isotope dilution mass spectrometry (IDMS). In addition, the employment is linked to a project aimed at developing a reference measurement procedure for the biomarker neurofilament light chain (NfL) in plasma. 

The duties encompass sample preparation, LC–MS analysis, data processing, and statistical analysis. The employment also includes administrative tasks related to the projects, such as compiling, documenting, and reporting results.

Eligibility

The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg.  

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.  

To qualify as a postdoctoral researcher for this employment, the applicant should hold a PhD in biomedicine, neurochemistry, neuroproteomics, or related fields.

Assessment

The successful candidate should have research experience in proteomics, biomarker research, and neurological or neurodegenerative diseases. Experience with high-resolution mass spectrometry and bioinformatic analysis of proteomics data is considered an advantage. 

Additional desirable qualifications include the ability to work independently with complex datasets, coordinate research projects, and interact effectively with collaborators. Great emphasis will also be placed on personal suitability.

Employment

The employment is limited (temporary) for 2 years, 100% of full-time, and is placed at the Institute of Neuroscience and Physiology. Starting date: as soon as possible or as agreed. 

Contact information 

If you have questions regarding the employment please contact Researcher Johan Gobom, phone: +46 730 229 028, e-mail: johan.gobom@neuro.gu.se

Manager in charge is Professor/Head of Department Henrik Zetterberg, phone: +46 768 672 647, e-mail: henrik.zetterberg@clinchem.gu.se

Application documents are not to be submitted through the contact persons.

Unions

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply

Application

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

Please enclose PhD certificate with the application.