项目介绍

2025年1月10日

A PhD Student position is available in the group of Prof. Dr. Karl Gademann, located in the Department of Chemistry at the University of Zurich (Switzerland). Our group combines the synthesis of natural and non-natural compounds with biological studies to answer questions about structure, function, biosynthesis, and mechanism of action. Please find further information on our website.

We offer an exciting PhD Student position in a stimulating and challenging environment directed towards the investigation of novel peptides and derivatives at the interface of chemistry and biology. You will be trained in automated peptide synthesis technology, synthetic organic chemistry, and analytical methods. The ambitious PhD project centers around the total synthesis of peptide natural products and selective peptide modification reactions and is set in a highly stimulating environment with state-of-the-art equipment and infrastructure, ensuring its successful implementation. Furthermore, you will have unique opportunities to develop a strong interdisciplinary portfolio, fostering personal and professional growth.

Your responsibilities

Within this project, you will employ a variety of tools in the broader field of peptide natural product synthesis and modification. You will design, synthesize and modify amino acids, and will use them in peptide synthesis using automated and manual synthesis platforms. You will be driving the characterization of chemically synthesized peptides using various analytical techniques (UHPLC, LCMS, CD, etc.).

Your profile

We are looking for a highly motivated, curious, and enthusiastic PhD student for a four-year research project at the University of Zurich. You should hold a Master’s degree in chemistry or similar fields, and should have solid expertise in organic chemistry. Expertise in peptide chemistry (SPPS) is a plus, but not required. You are adept at working in an open, interdisciplinary, and collaborative environment that you will contribute to with curiosity, scientific agility, self-motivation, and strong communication skills.

Information on your application

Your application should contain:

• letter of motivation
• curriculum vitae
• short summary of past research accomplishments
• transcripts of your academic records from your University, and a copy of your degree
• contact details of two referees (e.g. your M.Sc. thesis supervisor)

Please submit your application as a single PDF. Incomplete applications will not be considered.

Questions about the job

Prof. Dr. Karl GademannGroup Leader