项目介绍

2024年4月12日

A PhD project is available in the group of Prof. Dr. Alexandria (Ali) Deliz Liang in the Department of Chemistry at the University of Zurich (Switzerland). Our laboratory works on advanced methods in protein engineering including genetic code expansion. Currently, we are seeking a highly motivated PhD student to work on development and application of a novel protein engineering method.

Your responsibilities

The successful candidate will

• clone plasmids for protein expression,
• optimize protein expression and purification methods,
• develop assays for screening enzymatic activity (absorbance, fluorescence, HPLC-MS),
• perform high-throughput expression and screening of enzyme variants,
• engineer enzymes using directed evolution, and
• characterize the engineered enzymes.

Although no candidate will be expected to have experience in all the fields above prior to joining, an enthusiasm to learn these techniques is essential.

Your profile

• A highly motivated student with an MS degree in biochemistry, chemistry, or related field
• Enthusiastic about learning and applying new techniques
• Essential experience: cloning, protein expression and purification, enzyme assays
• Beneficial experience: cell-free protein expression, enzyme assay development, directed evolution, protein engineering
• Excellent communications skills in English (spoken and written) are essential
• Conscientious and inclusive working style

What we offer

We offer comprehensive training in a highly interdisciplinary laboratory. Students will be provided the opportunity to learn high-value techniques for future careers in academia or industry. Additionally, the laboratory is situated centrally in Zurich (Irchel), which offers a diverse and international environment.

Place of work

University of Zurich Irchel, Winterthurerstrasse, Zürich, Switzerland

Start of employment

The employment start date will be mutually agreed upon with the applicant and PI (approximate timeline between June 2024 and January 2025).

Applicants should submit a single PDF document that includes the following: i) a cover letter describing previous research and motivation for applying to this position, ii) a detailed curriculum vitae, and iii) the names of two people who can supply reference letters. Applications should be submitted via the link below. Applications will be assessed on a rolling basis until 01 September 2024. Given the rolling assessment of applications, candidates are encouraged to apply early.