项目介绍

2026年4月27日

We are a dynamic, interdisciplinary, medium-size lab working at the interface of chemistry and biology. We work on the development of probes to visualize and control biological processes in living systems. World-class infrastructure is available in our lab, the department, or at technology platforms of the University of Zurich. We are located at University of Zurich, Irchel campus, where you would work in one of the newest and most modern science buildings in Europe.

The Laboratory of Chemical and Biological Probes (Prof. Rivera Fuentes) is looking for a PhD student to work on the development of novel chemical tools to study redox biological processes. The following two recent publications are indicative of ongoing work of our lab in this area: Nat. Chem. 2023, 15, 1415; Redox Biol. 2025, 81, 103560. See also the group’s website for more information.

Your responsibilities

As a PhD student working on any of these projects, you would model protein-based fluorescent sensors using the latest artificial intelligence algorithms. You would clone, express and purify proteins, and characterize them spectroscopically and structurally by various techniques, including X-ray crystallography. You would also clone vectors for expression in mammalian cells to enable live-cell imaging experiments. In all cases, you would be expected to use state-of-the-art data analysis methods, including machine learning, to gain insight from your observations. Later in the project, you would work collaboratively to develop stable cell lines using genome editing techniques and contribute to a large knock-out screening campaign. This position involves very little to no synthetic organic chemistry. Additionally, you would be an active member of our group, contributing to routine lab maintenance, participating in group meetings and in selected outreach activities. You would also contribute to teaching as assistant in lab courses and lectures. You would also write reports and papers, and prepare presentations for national and international conferences.

Your profile

Highly motivated student with a solid background in molecular biology or biochemistry. A background in synthetic organic, inorganic or materials chemistry, engineering, or theoretical chemistry, with no experience in molecular biology, cell biology, or biochemistry is not suitable for this position. Strongly interested in developing new technologies to visualize proteins in complex biological samples and elucidate mechanisms in redox biology. Previous experience in de novo protein design, directed evolution, redox biology, bioinformatics and/or machine learning is an advantage. MSc degree in chemistry, biochemistry, molecular biology, or bioengineering and proficiency in oral and written English are formal requirements.

Information on your application

Please submit your application as a single PDF file including a motivation letter including a concise summary of your research experience, CV and copy of transcripts. Letters of recommendation will only be required for shortlisted candidates. Applications will be received until May 31, 2026. Incomplete applications or those arriving after the deadline will not be considered.