项目介绍

2024年3月28日

The Department of Molecular Medicine (IMM) aims to generate new knowledge on the function of the human body and disease mechanisms, thereby contributing to improved human health. IMM hosts an interdisciplinary group of experts in neurobiology and cancer biology and is in close proximity to the experts in genomics, proteomics and chromatin biology. Such a promising environment elicits translational collaborations with clinical practice and research toward understanding mechanisms underlying the pathophysiology of various human diseases.

Applications are invited for a PhD position in Bioinformatics in the laboratory of DNRF Chair and Novo Nordisk Faculty Prof. Vijay Tiwari (https://www.tiwarilab.org/). Tiwari lab works on single-cell genomics and gene regulation, combining new single-cell and spatial omics technologies with bioinformatics and machine learning. In this project, the student will employ computational strategies to identify human genetic variation linked to cell fate changes in neurodevelopmental disorders and cancer. The candidate can use and combine single-cell ATAC-seq, single-cell RNA-seq, spatial gene expression, and whole-genome sequencing (with long reads) data. The candidate will get the opportunity to explore new analysis methods using deep learning. Depending on the interest, it is also possible to be involved in the wet lab, to perform single-cell sequencing and other experiments.

To learn more, please refer to the selected publications from the Tiwari lab:
EMBO Molecular Medicine, 2024, in press; Nature Communications, 2024, in press;  npj Precision Oncology, 2024, in press; Nature Cell Biology, 2022, 24, 1265–1277; Genes & Development, 2020, Sep; 34(17-18):1190-1209; Nature, 2019, Mar; 567(7746):113-117; Cell Stem Cell, 2018, Oct 4; 23(4):557; Nature Communications, 2017 Nov 15;8(1):1523; The EMBO Journal, 2016 Jan 4;35(1):24-45; J Cell Science, 2015 Dec 1;128(23):4380-94; The EMBO Journal, 2015 Aug 13;34(16):2162-81; Genome Research, 2015 Sep;25(9):1309-24; Nature Communications, 2013, Sep 27; 4:2478; Cancer Cell, 2013, 23, 768-783; PNAS, 2012 Apr 17;109(16): E934-43; Nature Genetics, 2012 Jan; 18;44(1):94-100;  Nature, 2011 Dec 14;480 (7378):490-5.    

You will
•   Employ new computational strategies to identify human genetic variation linked to cell-fate changes in neurodevelopmental disorders and cancer. 
•   Analyze bulk, single-cell and multi-omics datasets
•   Lead projects on gene regulatory mechanisms that contribute to the development and disease
•   Maintain accurate and detailed records of research activities 
•   Gain training in internationally competitive and multidisciplinary Data Science research

Required Qualifications
•   MSc in Bioinformatics, Computer Science, Physics, Engineering, Bio-engineering, or equivalent. 
•   Experience in Programming (R and/or Python). 
•   Strong analytical, organizational, and record-keeping skills
•   Interest in working in a multidisciplinary and multicultural team 
•   Willing to collaborate with internal and external collaborators

We offer 
•   The possibility to engage in high-impact, multidisciplinary research
•   A stimulating, diverse and international research environment 
•   Full funding for three years
•   Advanced training opportunities 
•   Highly motivated research team and international collaborations
•   Access to state-of-the-art equipment and facilities
•   A supportive scientific and social network, including mentoring and career development
•   A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
•   Support with practical, social, and legal aspects (e.g. housing, visa, tax etc.) through our international staff office (ISO) and the Department

Application should be in the form of declaration of interest and include
•   A letter stating your specific interest, motivation, and qualifications for the Tiwari laboratory and project (max. two pages).
•   A detailed CV, including personal contact information (max three pages).
•   Master’s degree.
•   Contact details of two referees.
 

Apply
Applications must be submitted electronically using the link “Apply now” latest on May 15th, 2024.

The attached files must be in PDF format. The application and CV must not exceed 10 MB in total. We strongly recommend that you read How to apply before you apply. Only applications submitted online and written in English will be accepted for evaluation. Applications may be shortlisted. Incomplete applications and applications received after the deadline will neither be considered nor evaluated. 

Successful candidates will be asked to send an application to the PhD Secretariat, Faculty of Health Sciences, to be enrolled as PhD students. 

The PhD programme will be carried out in accordance with Faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order)”
For further information, please contact Professor Vijay Tiwari at tiwari@health.sdu.dk

Living and Working in Denmark

Foreign applicants will be offered Danish language training as part of the employment. The International Staff Office (ISO) at SDU provides a variety of services for new employees, guests and people who consider applying for a job at the University of Southern Denmark. Among other things, the staff answers questions concerning salary, taxation, housing and accompanying family. 

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Deadline for Applications: May 15th 2024.