哥德堡大学

Medical Science – Translational pediatric cancer research

项目介绍

The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Project title:
Personalized analysis of circulating tumor DNA: A non-invasive guide for treatment decisions in children with hematological malignancies

Job assignments

The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies

Project: Circulating tumor DNA (ctDNA) is fragmented genetic material that continuously leak out from dying tumor cells into the blood plasma. As it harbors genetic alterations specific for the patient’s cancer cells, ctDNA can be quantified using targeted DNA sequencing. The aim of this doctoral project is to test the hypothesis that personalized analysis of ctDNA in peripheral blood may be used as a marker for treatment response in children with hematological malignancies.

We will analyze blood samples from children with leukemia or lymphoma, treated at Sahlgrenska University Hospital. Patient-specific and highly sensitive will be developed in order to achieve the bet possible tumor marker. To evaluate the results, we will correlate the ctDNA levels to clinical information regarding treatment effect and patient outcome.

If proven successful, this method may be used to guide treatment decisions, contributing to higher survival rates and less side effects in children with hematological malignancies. It may also reduce the need for more invasive and potentially harmful methods of monitoring disease burden, such as repeated CT scans in lymphoma patients and bone marrow biopsies in children with leukemia.

More information about the research group can be found here: https://www.gu.se/en/research/martin-dalin 

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
– specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Documented experience in circulating tumor DNA, plasma DNA extraction, PCR primer design and targeted sequencing is meritorious. Personal suitability is important, as the position requires commitment, initiative and cooperation skills.

Employment

After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Pediatrics. Extent: 100%. First day of employment: as agreed.

Salaries for doctoral students are regulated in a local agreement at the University. 

For further information regarding the position

For more information about the project please contact the principal supervisor, 
Martin Dalin, Associate Professor, Institute of Clinical Sciences,
e-mail: martin.dalin@gu.se 

Unions

Union representatives at the University of Gothenburg:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/how-to-apply

Information for International Applicants

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

https://www.gu.se/en/about-the-university/welcome-services

https://www.movetogothenburg.com/

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of  English 6 course or the acquired equivalent knowledge through previous studies

If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier 

If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/

Closing date: 2021-05-25

录取要求

  • A person meets the general entry requirements for third-cycle studies if he or she: 1. has been awarded a second-cycle qualification 2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or 3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad
  • A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

项目概览

wave-1-bottom
访问项目链接 招生网站
北欧, 瑞典 所在地点
带薪项目 项目类别
截止日期 2021-05-25
哥德堡大学

院校简介

哥德堡大学是瑞典的一所世界一流综合性研究型大学。
查看院校介绍

联系方式

电话: +46 31-786 00 00

相关项目推荐

KD博士收录了全球400所院校的博士项目,总有一个项目等着你!