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The Department of Molecular and Clinical Medicine at the Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, conducts translational research primarily on metabolism, diabetes, obesity and cardiovascular disease in order to improve health and healthcare in the community. The overall goal is to create an excellent translational research environment of a very high international standard.
Project title: Pathophysiology of takotsubo syndrome
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Takotsubo syndrome (TS), also known as broken heart syndrome, is a relatively new diagnosis and was first reported in 1991. The syndrome is more common in women (80% of all patients) than men and it is often triggered by emotional stress. The syndrome is characterized by the development of extensive but transient muscle paralysis that affects two-thirds of the left ventricle. This can cause severe heart failure, heart rupture and ventricular fibrillation and can lead to death. Our research has shown that TS is associated with significant short-term (4%) and long-term (10%) mortality that is on par with mortality after myocardial infarction. Approximately 10% of patients with TS develop complications, including cardiogenic shock, thromboembolism during the acute period. Based on data from the Swedish national SCAAR/SWEDEHEART register, we estimate that ~ 2000 patients per year develop TS in Sweden.
The overall purpose of the research is to investigate how to improve the prognosis for TS by better understanding the mechanisms behind extensive ‘myocardial stuning’ (sudden, but reversible loss of cardiac function) to increase and optimize cardiac function. This will be achieved through a combination of studies at different levels; epidemiological, clinical and experimental models. The doctoral student will work with the rat model of TS that is established in our group. The focus will be on the mechanisms behind myocardial stunning in TS and how it differs from myocardial stunning in myocardial ischemia/myocardial infarction. Data from experimental studies will be compared to parallel studies in patients with TS and myocardial infarction. The rat model of TS will be further developed to best reflect the clinical course of the syndrome. The experimental model will allow for experiments based on the observations we make in the clinical model. Treatment strategies that are successful in the experimental model will be tested in human trials.
Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.
To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.
A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad
A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies
In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
– specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.
Location: Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine. Extent: 100%. First day of employment: as agreed.
Salaries for doctoral students are regulated in a local agreement at the University.
For further information regarding the position
For more information about the project please contact the principal supervisor,
Elmir Omerovic, Professor, Institute of Medicine,
phone:+46 70 456 0787, e-mail: firstname.lastname@example.org
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How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
You must include the following, in pdf format
- Personal letter
- Diploma and transcripts showing that you meet with the general entry requirement
- Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/
Closing date: 2021-05-25