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The Department of Clinical Neuroscience is located in the Institute of Neuroscience and Physiology at the Faculty of Health Care Sciences at the Sahlgrenska Academy, University of Gothenburg. The department conducts research in neurology, neurosurgery, clinical neurophysiology, ophthalmology, rehabilitation medicine and experimental neuroscience in close collaboration with the Sahlgrenska University Hospital. The department is responsible for courses in the educational programs for prospective physicians, biomedical analysts, occupational therapists, physiotherapists and speech therapists. We also carry out commissioned educational programs in collaboration with the Department of Neurology at the Sahlgrenska University Hospital. There are around twenty research groups at the department.
Project title: The Role of Hypoxia-Inducible Factor-Prolyl-Hydroxylase in Perinatal Brain Injury
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Despite major improvements in maternal care, obstetrics and neonatology, the number of newborn children suffering from brain injuries occurring around birth is increasing. Perinatal brain injury is the primary cause of cerebral palsy, which is the most common cause of motor dysfunction in children and young people. These children will be subject to life-long, extensive and costly care and rehabilitation. Currently, the mechanisms of perinatal brain injury are not fully understood. The only therapeutic option is hypothermia which only provides partial brain protection and can only by used in term babies in high resource settings. The overall purpose of this PhD project is to develop an in-depth understanding of the mechanisms of brain injury and to conduct translational studies with the goal of preventing perinatal brain injury and improving functional recovery in newborn infants.
In order to better understand the processes involved in perinatal brain injury, we will focus on hypoxia-inducible factor (HIF) prolyl-4-hydroxylases (PHDs), which has emerged as promising target candidates for mitochondrial protection in paradigms of oxidative stress associated with ferroptosis and necroptosis. We will apply genetic approaches to study the role of HIF-PHD in neuronal cell death and study the therapeutic potential of pharmacological inhibition of HIF-PHD or ferroptosis in development of cell death in perinatal brain injury. The mechanistic insights into perinatal brain injury gained from these investigations will ultimately lead to the development of novel intervention and repair strategies for reducing neurological handicaps and improving the quality of life for patients with perinatal brain injury.
We welcome applicants who are highly motivated, with an interest in perinatal brain injury.
Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.
To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.
A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad
A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies
In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
– specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.
Location: Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience. Extent: 100%. First day of employment: as agreed.
Salaries for doctoral students are regulated in a local agreement at the University.
For further information regarding the position
For more information about the project please contact the principal supervisor,
Changlian Zhu, Associate Professor, Institute of Neuroscience and Physiology,
Union representatives at the University of Gothenburg:
Information for International Applicants
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How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
You must include the following, in pdf format
- Personal letter
- Diploma and transcripts showing that you meet with the general entry requirement
- Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/
Closing date: 2021-11-08