苏黎世联邦理工

Hypoxia-mediated Pexophagy and the Role of Peroxisomes in Cancer

项目介绍

From January 2021, the Molecular Oncology Lab, headed by Prof. Nicola Aceto, is located at the Institute of Molecular Health Sciences of the Department of Biology (D-BIOL) within the ETH Hönggerberg campus, the Life Science Campus of ETH Zurich, and comprise a team of dedicated scientists and collaborators across different clinics and pharmaceutical companies.

Project background

The group of PD Dr. Werner Kovacs combines a wide variety of disciplines to answer outstanding questions in cancer research, with a particular emphasis on the molecular mechanisms of HIF-2a-mediated pexophagy and the role of peroxisomes in tumorigenesis and metastasis. Investigations will range from the study of the mechanisms of HIF-2a-mediated pexophagy, screens to identify regulators of HIF-2a-mediated pexophagy and therapeutic candidates for clear cell renal cell carcinoma and hepatocellular carcinoma, and the role of altered peroxisome abundance in metabolic reprogramming and tumor growth. These studies will involve the application of state-of-the art genomics, biochemical/cell/ molecular biological and screening technologies and the use of mouse models of cancer. The position offers excellent scientific opportunities in a highly stimulating and interdisciplinary environment involving close interactions between scientists from different disciplines.

Job description

We seek a highly motivated PhD student interested in studying the molecular mechanisms of HIF-2a-mediated pexophagy and the role of peroxisomes in tumorigenesis.

Your profile

Our ideal candidate is:

  • A highly motivated applicant with a MSc or MD degree and a strong background in biochemistry, cell and molecular biology, genetics, cancer research and pathophysiology. 
  • Familiar with cell culture and molecular biology and willing to work with mice
  • Excited to work in a highly-collaborative environment that includes molecular biologists, clinicians, and computational biologists
  • Capable of independent thinking, ambitious, focused on discovery and dedicated to perform research of the highest quality 
  • A team player with excellent communication and writing skills (English)

Interested?

Please submit your online application including the following documents:

  • CV
  • Motivation Letter
  • References (or contact details of referees)

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

For more information please visit our website. Questions regarding the position should be directed to PD Dr. Werner Kovacs, email: werner.kovacs@biol.ethz.ch (no applications).

录取要求

  • A highly motivated applicant with a MSc or MD degree and a strong background in biochemistry, cell and molecular biology, genetics, cancer research and pathophysiology.
  • Familiar with cell culture and molecular biology and willing to work with mice
  • Excited to work in a highly-collaborative environment that includes molecular biologists, clinicians, and computational biologists
  • Capable of independent thinking, ambitious, focused on discovery and dedicated to perform research of the highest quality
  • A team player with excellent communication and writing skills (English)

项目概览

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欧陆, 瑞士 所在地点
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截止日期 2021-10-06
苏黎世联邦理工

院校简介

苏黎世联邦理工是国际研究型大学联盟、全球大学高研院联盟、IDEA联盟成员,是闻名全球的世界顶尖研究型大学,连续多年位居欧洲大陆高校翘首。
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联系方式

电话: +41 44 632 11 11

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