奥斯陆大学

Gene editing and cell-based therapy

项目介绍

Job description

Are you interested in applying state-of-the-art technologies to develop new treatment possibilities for patients with inherited bleeding disorders?

We are seeking a PhD candidate to join our research team in this exciting project funded by the Norwegian Research Council. The position is affiliated with the Institute of Clinical Medicine, Division of Cancer Medicine at the University of Oslo, but your daily work place will be at Oslo University Hospital, Rikshospitalet. The research group has conducted basic, translational and clinical research for more than 30 years, with a focus on blood coagulation factors and their role in disease.

More about the position

In the project, you will work on a bleeding disorder called inherited factor (F) VII deficiency. FVII is a vital protein in the blood coagulation process and an inherited deficiency of this protein is caused by mutations in the F7 gene leading to severely reduced activity of the FVII protein in the blood. Clinically, these patients experience frequent and sometimes severe bleeding episodes, and the only treatment today is replacement therapy that is expensive and invasive. We are using CRISPR gene editing and advanced cell reprogramming techniques to correct the mutation in the patients’ own cells and establishing transplant procedures in mice models to restore FVII activity and function. These important pre-clinical studies will lay the foundation for cell-based therapies in patient with FVII deficiency.

You will work closely with an experienced researcher and a postdoctoral fellow on the project. The position is over a three-years period. 

The research fellow must take part in the Faculty’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.

Qualification requirements

  • MD or MSc (or equivalent) in relevant topic
  • Ability to design, plan, and execute experiments
  • Experience in molecular biology techniques such as cell culturing, cloning, qPCR, ELISA, Western blotting, Immunohistochemistry (requirement)
  • Formal accreditation (FELISA C or similar) and experience working with mice models is an advantage
  • Experience with CRISPR gene editing, stem cell work, and in vivo transplants is an advantage
  • Proficient in English language, both written and oral.

For applicants who have yet to receive their Master’s degree, the Master’s thesis must have been submitted for evaluation before the application deadline. Such applicants should note the date of submission of their Master’s degree in the cover letter. Appointment is dependent on the master thesis being approved. The candidate will admit to the PhD program at the Faculty of Medicine  (see How to apply for admission to the PhD programme – Faculty of Medicine (uio.no) for requirements).

Personal skills

  • Excellent communication and team working skills
  • Organized and structured
  • Flexible
  • Enthusiastic and willing to learn new methods and techniques

When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project.
Applicants may be called in for an interview.

We offer

  • Salary NOK 491 200 – NOK 534 400 per annum depending on qualifications in a position as PhD Research fellow, (position code 1017)
  • A professionally stimulating working environment
  • Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities
  • interest organization for PhD and postdoctoral fellows Home – UiODoc

How to apply

The application must include:

  • Cover letter (statement of motivation, summarizing scientific work and research interest).
  • CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activities).
  • Copies of educational certificates (academic transcripts only).
  • Any research publications that the applicant wishes to be considered.
  • List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number).

The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”. Foreign applicants are advised to attach an explanation of their University’s grading system. Please note that all documents should be in English (or a Scandinavian language).

Formal regulations

Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.

No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. We also want to have employees with diverse expertise, combinations of subjects, life experience and perspectives. We will make adjustments for employees who require this. 

If there are qualified applicants with special needs, gaps in their CVs or immigrant backgrounds, we will invite at least one applicant in each of these groups to an interview.

Contact information

Project leader, professor Per Morten Sandset  email: p.m.sandset@medisin.uio.no

Researcher, Maria Eugenia Chollet Dugarte email: m.e.c.dugarte@ous-research.no

Questions regarding the online application form can be directed to Senior HR Adviser Thoril Kristiansen email: thoril.kristiansen@medisin.uio.no

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截止日期 2021-11-01
奥斯陆大学

院校简介

奥斯陆大学是挪威规模最大、国际声誉最高、历史最悠久的综合性大学。
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联系方式

电话: (+47) 22 85 50 50

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