卡罗林斯卡医学院

Cancer immunotherapy

项目介绍

Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

Assistant Professor Dr. Mattias Carlsten M.D. Ph.D. is heading a translational research group at the Karolinska Institute (KI) with close connection to the Cell Therapy and Allogeneic Stem Cell Transplantation unit at the Karolinska University Hospital. The group is located at HERM, Department of Medicine, Huddinge (MedH), KI. The main research focus of Dr. Carlsten’s group is to study how NK cells and T cells can be utilized to treat cancer (Childs et al. Nature Reviews Drug Discovery 2015, Björklund, Carlsten, Sohlberg et al. Clin. Can. Research 2018, Levy et al. Frontiers in Imm. 2019, Leijonhufvud et al. Clin & Trans Imm 2021). More specifically, the group focuses its work around basic biology as well as genetic engineering of NK cell and T cells to redirect their homing and target specificity with the overall aim of applying new discoveries in settings of cellular cancer immunotherapy. As a physician-scientist, Dr. Carlsten’s work bridges pre-clinical in vitro studies, from molecular and cellular biology to animal models, and early clinical trials involving cellular cancer immunotherapy. As part of the overall goal, the group will now also start to address how genetic engineering of NK cells can be utilized to improve their persistence after adoptive transfer and thereby augment their anti-tumor targeting capacity. This will be done in close collaboration with Prof. Yenan T. Bryceson at HERM, KI, and Dr. Suman Mitra at University of Lille, France.

The doctoral student project and the duties of the doctoral student

A key factor that has limited the success of NK cell-based protocols for the treatment of cancer is the inability of the infused cells to persist. This project will attempt to generate long-lasting NK cells and address if they can be used to promote better and more durable anti-tumor responses. Genetic engineering of NK cells via transfection and transduction will primarily be used to generate these NK cells, while gene expression arrays and CRISPR-Cas9-based methods will also be used to identify and confirm key genes involved in forming and/or controlling NK cell persistence. As part of the project, the student will address the role of transcription factors to generate memory-like NK cells. As a parallel route, the student will work with synthetic molecules to promote NK cell persistence, alone or in combination with receptors that redirect the NK cell specificity towards tumor cells. NK cell survival after adoptive transfer and the impact of sustained in vivo persistence of the NK cells in controlling tumor growth will be addressed in animal models. Designing and cloning of DNA constructs will be a central part of the project. The project will also involve an array of other cellular and molecular biology techniques and assays along with advanced methods of analysis. The position provides an exciting opportunity for the successful candidate to apply and develop cutting-edge technology and excel in the space between bench work, animal work and clinical studies with the overall aim of establishing new concepts to improve the therapeutic efficacy of NK cell-based cancer immunotherapy. As the supervisor constellation and their respective groups have complementary expertise and insights stretching from transcriptional programs of NK cells via genetic engineering, cytokine signaling and animal models to clinical practice and early phase clinical trials, the student will have the chance to learn and get support along the research spectra from bench to bedside. The supervisors expect a dedicated student with a burning interest in gaining new insights into how immune cells can be manipulated and utilized for enhanced therapeutic features. To succeed with this prospective experiment-based PhD project, the student will be required to work actively in the laboratory in addition to data analysis, manuscript writing, and attending seminars, group meetings and the mandatory doctoral training courses.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

项目概览

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北欧, 瑞典 所在地点
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截止日期 2021-12-09
卡罗林斯卡医学院

院校简介

卡罗林斯卡医学院,是瑞典著名的医学院,也是世界医学排名前十的医学院之一。
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联系方式

电话: 08-524 800 00

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