Are you looking for a PhD Position where you can have impact on the lives of people? Are you interested in the effects of Amylase Trypsin Inhibitors (ATIs) and how to modify these? Do you want to work with a number 1 employer in education and research? We have a vacancy for a PhD in ATI protein modification.
In this project, called “Modification of functional properties of Amylase Trypsin Inhibitors (ATIs) by REDOX reactions to mitigate pathogenic effects”, you will work in the Laboratory of Food Chemistry and FFC Food, Health & Consumer Research, Food & Biobased Research of Wageningen University and Research (WUR). The project aims to modify the functional properties of wheat Amylase Trypsin Inhibitors (ATI) via REDOX reactions in model systems and in situ during cereal processing (companies). Next to enzyme inhibitory activities of ATIs, that can have a negative impact on the digestibility of cereal based foods, they are the main cause of bakers allergies and play possibly a role in irritable bowel syndrome and non-coeliac wheat sensitivity.
- Modify ATIs in isolated form, and in situ during processing cereal based products by various redox reactions;
- characterize the extent and location of modifications;
- investigate ATI’s properties and functionality by LC-MSMS, in vitro digestibility studies and enzyme inhibition studies and in vitro intestinal cell binding, cell modulation and immunomodulation.
Based on the outcomes, a food grade modification will be selected and upscaled for clinical trials in humans, to be executed by the Maastricht University (as consortium partner) to confirm the positive and/or negative effects in vivo.
The research is embedded within the chair Laboratory of Food Chemistry, which is led by Prof. Jean-Paul Vincken. You will be co-supervised by dr. Peter Wierenga, assistant professor in Protein Biochemistry and dr. Peter Weegels, researcher Technology of Cereal product digestibility and dr. Shanna Bastiaan-Net researcher FFC Food, Health & Consumer Research from WUR FBR.
- A successfully completed MSc degree in the field of (Analytical) Chemistry, Food Chemistry, Biotechnology or Molecular Life Sciences and affinity to protein chemistry/enzymology/ biofunctionality;
- experience in protein characterization with chromatography, mass spectrometry, NMR and/or cell-culture based assays (intestinal and immune cells) and knowledge in immunology and gut microbiology is a benefit;
- intrinsic interest to independently search for answers on fundamental and applied research questions;
- excellent research skills;
- ability to excel in a multi-disciplinary project;
- excellent English language proficiency (a minimum of CEFR C2 level). For more information about this proficiency level, please visit our special language page.
Wageningen University & Research offers excellent terms of employment. A few highlights from our Collective Labour Agreement include:
- Sabbatical leave, study leave, and paid parental leave;
- working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
- the option to accrue additional holiday hours by working more, up to 40 hours per week;
- there is a strong focus on vitality and you can make use of the sports facilities available on campus for a small fee;
- a fixed December bonus of 8.3%;
- excellent pension scheme.
In addition to these first-rate employee benefits, you will receive a fully funded PhD position and you will be offered a course program tailored to your needs and the research team.
The gross salary for the first year is € 2.395,- per month rising to € 3.061,- in the fourth year in according to the Collective Labour Agreements for Dutch Universities (CAO-NU)(scale P). This is based on a full-time working week of 38 hours. We offer a temporary contract for 18 months which will be extended for the duration of the project if you perform well.
There are plenty of options for personal initiative in a learning environment, and we provide excellent training opportunities. We are offering a unique position in an international environment with a pleasant and open working atmosphere.
You are going to work at the greenest and most innovative campus in Holland, and at a university that has been chosen as the Best University in the Netherlands for the 16th consecutive time.
Coming from abroad
Wageningen University & Research is the university and research centre for life sciences. The themes we deal with are relevant to everyone around the world and Wageningen, therefore, has a large international community and a lot to offer to international employees. Applicants from abroad moving to the Netherlands may qualify for a special tax relief, known as the 30% ruling. Our team of advisors on Dutch immigration procedures will help you with the visa application procedures for yourself and, if applicable, for your family.
Feeling welcome also has everything to do with being well informed. Wageningen University & Research’s International Community page contains practical information about what we can do to support international employees and students coming to Wageningen. Furthermore, we can assist you with any additional advice and information about helping your partner to find a job, housing, schooling, and other issues.
Do you want more information?
For more information about this position, please contact Dr. Peter Wierenga, assistant professor in Protein Biochemistry at FCH, telephone: +31 31748786, Dr Peter Weegels, researcher Technology of Cereal Product Digestibility FCH, email: email@example.com, or Dr. Shanna Bastiaan-Net FFC Food, Health & Consumer Research from WUR FBR, telephone: +31 317487611.
For more information about the contractual aspects, please contact HR advisor Ina Lüttmann by email: firstname.lastname@example.org.
Do you want to apply?
You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval.
This vacancy will be listed up to and including June 30th 2021. We hope to schedule the first job interviews week 27 2021. The preferred starting date for this position is August 1.
Wageningen University & Research (WUR) employs a large number of people with very different backgrounds and qualities, who inspire and motivate each other. We want every talent to feel at home in our organisation and be offered the same career opportunities. We therefore especially welcome applications from people who are underrepresented at WUR. For more information please go to our inclusivity page . A good example of how WUR deals with inclusiveness can be read on the page working at WUR with a functional impairment.