项目介绍

2026年4月22日

Description

At the Gote-Schniering Lab of the University of Bern, we are seeking a highly motivated PhD candidate to investigate immune ageing mechanisms in fibrotic lung disease.

With ageing, the lung progressively loses its regenerative capacity after injury, which can contribute to diseases such as pulmonary fibrosis. Increasing evidence suggests that immune ageing plays an important role in this process. This project will investigate how age-related changes in the immune system impair lung repair and promote fibrosis. Using single-cell and spatial omics, imaging, and human 3D tissue models, the aim is to uncover key mechanisms and identify new therapeutic opportunities.

Tasks

• generate and analyze single-cell and spatial transcriptomics / proteomics datasets,
• perform functional assays and mechanistic perturbation experiments,
• work with ex vivo 3D lung tissue culture models,
• contribute to experiments in in vivo mouse models,
• collaborate closely with researchers across immunology, lung biology, and computational biology.

Requirements

• a Master’s degree in Bioinformatics, Computational Biology, Systems Biology, Biomedical Engineering, or a related field,
• strong programming and data analysis skills (e.g., Python, R),
• a strong interest in translational biomedical research, disease mechanisms, and multimodal data integration,
• motivation to work in an interdisciplinary research environment.

The following are considered an advantage:

• experience in medical image analysis / radiomics,
• experience with single-cell or spatial omics,
• knowledge of machine learning / deep learning.

We offer:

pplication and Contact

Please send your complete application, including motivation letter, CV, academic record incl. grades, BSc and MSc diploma, and two reference letters as a single pdf file to: janine.gote-schniering@unibe.ch. The deadline for application is 10.05.2026.

Questions about the position?

For subject-specific questions and information about the position, please contact janine.gote-schniering@unibe.ch

Questions about the application?

janine.gote-schniering@unibe.ch

• a highly interdisciplinary PhD project at the interface of immunology, tissue regeneration, and systems medicine,
• access to cutting-edge technologies including single-cell omics, spatial profiling, and 3D tissue models,
• a collaborative and internationally connected research environment,
• strong opportunities for scientific development, publication, and career growth.