项目介绍

2026年4月9日

About the position 

A 3-year postdoctoral fellowship is available at the Department of Immunology, Institute of Clinical Medicine, University of Oslo. The position will be located in the lab of Professor Ludvig M. Sollid and will be available from July 2026.

The research group studies functional immunogenetics and adaptive immunity – particularly in relation to autoimmune diseases (https://www.med.uio.no/klinmed/english/people/aca/lmsollid/index.html).

Recently, B-cell depletion therapy has emerged as a promising treatment for several autoimmune diseases. However, we do not fully understand the pathogenic role of B cells. To gain insight into disease mechanisms, we employ a combination of biochemical assays, structural studies and high-throughput sequencing analyses of single cells isolated from patient samples. This position is part of a new translational research center (KG Jebsen Center for Specific Autoimmune Therapy) aiming to develop antigen-specific B-cell depletion strategies for treatment of autoimmune diseases. The work will be carried out in close collaboration with other researchers and clinicians at Diakonhjemmet Sykehus and Oslo University Hospital.

Project description

The successful candidate will work on a project that aims to identify antigen-specific B cells in rheumatoid arthritis. This is a common disease which currently is treated with drugs that curb inflammation, but which do not interfere with the underlying pathogenic immune responses. While deep B-cell depleting therapies also appear to be effective for rheumatoid arthritis, removal of all B cells leaves patients immunocompromised. The project will explore the possibility of targeting only the disease-causing fraction of B cells by employing antigen-specific depletion strategies. Ultimately, our goal is to develop precision medicine tools that can be used to treat a range of autoimmune diseases with a minimum of side effects.

Your main tasks will be 

• Isolation of antigen-specific B cells and plasma cells from patient samples
• Generation of recombinant monoclonal antibodies
• Generation of B-cell receptor transduced cell lines
• Antibody-antigen binding studies
• Targeting of B cells in in vitro assays
• Writing of scientific papers and presentation of results at international conferences

Qualifications

• PhD in immunology
• Experience with relevant techniques; flow cytometry including cell sorting, cell culturing, PCR, molecular cloning and ELISA 
• Experience with immune receptor sequencing 
• Experience with bioinformatics is an advantage
• Fluent in spoken and written English

 Personal skills 

We are looking for a highly motivated candidate with an outstanding potential and a strong background within a relevant research area. The candidate should be able to work independently as well as in a team and should actively contribute to both the design and conduction of research experiments.

We need different perspectives in our work 

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no.

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will do our best to accommodate your needs. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.

More information about gender equality initiatives at UiO can be found here.

We hope you will apply for the position with us. 

We offer 

• Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development.
• A pleasant and stimulating work environment 
• Good welfare schemes.
• Opportunity of up to 1.5 hours a week of exercise during working hours.
• A workplace with good development and career opportunities. 
• Membership in the Statens Pensjonskasse, which is one of Norway’s best pension schemes with beneficial mortgages and good insurance schemes.
• Salary in position as Postdoctoral Fellow, position code 1352 in salary range NOK from 595 000- to 695 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.

Read more about the benefits of working in the public sector at Employer Portal.

Application

Your application should include:

• Motivtation letter
• CV
• A complete list of publications
• Project description
• Transcripts and certificates
• Contact information for 2-3 references

Application with attachments must be submitted via our recruitment system Jobbnorge, click “Apply for the position”.

When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.