项目介绍

2025年1月8日

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The position is available in the Pan Hammarström Lab (https://ki.se/en/research/groups/pan-hammarstrom-lab), which is part of the Division of Immunology under the Department of Medical Biochemistry and Biophysics. The research group focuses on B cell in both normal physiology and disease pathology. Currently, there are four main topics in the group, including the development and diversifications of B cells, the discovery of therapeutic targets in B-cell lymphomas, the genetics of primary immunodeficiency, and antibody therapy against infectious diseases.  The team is interdisciplinary, comprising biologists, and computational biologists who collaborate to explore cutting-edge questions in B-cell immunology and malignancy. We offer a stimulating scientific environment and a top research infrastructure both locally, at the department level, and institution level.

The doctoral student project and the duties of the doctoral student

We are looking for a highly motivated PhD student with an interest in B-cell related diseases. The successful candidate will work on projects focused on B-cell malignancies, with the primary objective of understanding the development and progression of B-cell tumors using a genetically engineered organoid model. By utilizing this immune organoid system in combination with genome editing techniques, the candidate will identify key drivers and map the steps that lead to genome instability and malignant transformation in human B-cells. The role will also involve investigating the impact of viral infections on B-cell lymphomagenesis. This research aims to provide new insights into the mechanisms driving disease onset and progression, ultimately contributing to the development of innovative preventive and therapeutic strategies for B-cell lymphoma patients.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirementYou meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

To be eligible for employment as a PhD student, a master degree is required. This eligibility requirement must be met at the time the employment begins.

Preference will be given to the candidate who has:

• Academic qualification (master’s degree) in cell biology, immunology, or biotechnology and medical science-related fields.
• Research experience in B-cell immunology, tumor biology, molecular biology, infectious disease and/or cancer genomics.
• Experience in cell culture, immunological techniques (flow cytometry, cell sorting, ELISA, Western blot), molecular biology techniques (cDNA synthesis, PCR, qPCR, RNA/DNA isolation, cloning, DNA sequencing, CRISPR/Cas9 genome editing) and protein production and purification.
• Highly motivated with the ability to work both independently and collaboratively within a team.
• Fluent in spoken and written English

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.