项目介绍

2024年11月23日

The Department of Medical Biochemistry and Microbiology (IMBIM) at Uppsala University provides a broad international environment for research and teaching. Research at IMBIM) broadly spans the areas of biochemistry, cell and molecular biology, tumour biology, comparative genetics, functional genomics, immunology, bacteriology, and virology. The research is essentially of fundamental nature, but with relevance and application in health and disease in both animals and humans. More info: Research – Uppsala University

We seek a highly motivated individual, with an ability to work independently and a strong interest in pursuing a PhD degree in medical microbiology. The expected starting date is spring 2025, or as otherwise agreed.

Project description: The research group where the candidate will be joining is focusing on mechanisms and dynamics of plasmid copy number in pathogenic bacteria, with a strong focus on infection biology and evolution of antibiotic resistance. The goals for this project are i) to better understand the impact of plasmid copy number variation on antibiotic resistance, resistance evolution, and horizontal gene transfer, and ii) to investigate the detailed molecular mechanisms of gene copy number variation, with a strong focus on antibiotic-induced variations in plasmid copy number. To reach these goals, the successful candidate will have access to a large collection of genetically well-characterized microorganisms, infection models, cutting-edge tools (including ddPCR, Illumina and Nanopore sequencing), and an interactive and stimulating working environment.

Duties: The successful candidate will primarily engage in research work and doctoral studies. Other duties at the department are administration and teaching that may be included in the employment at a maximum level of 20 %.

RequirementsTo meet the entry requirements for doctoral studies, you must

• hold a Master’s (second-cycle) degree in Genetics, Microbiology, Evolutionary Biology or a related field, or
• have completed at least 240 credits in higher education, with at least 60 credits at Master’s level including an independent project worth at least 15 credits, or
• have acquired substantially equivalent knowledge in some other way.

We are looking for a candidate who has a strong interest in basic research in microbiology and bacterial genetics. Previous practical experience in microbiology and bacterial genetics is highly desired. Very good oral and written communication skills in English are required. Emphasis will also be given on personal qualities such as collaboration and communication skills as well as analytical capacity. Ability to take own initiatives as well as to work well independently and in interaction with other research groups is an asset.

Additional qualifications
Working knowledge in bioinformatics and statistics is highly appreciated.

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University’s rules and guidelines.

About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %.Starting date as soon as possibleor as agreed. Placement: Uppsala

For further information about the position, please contact: Asso. Prof. Helen Wang, helen.wang@imbim.uu.se.

Please submit your application by 5 December2024, UFV-PA 2024/4027.

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