项目介绍

2024年11月6日

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The Department of Medical Epidemiology and Biostatistics conducts research in epidemiology and biostatistics across a broad range of areas within biomedical science. The department is among the largest of its type in Europe and has especially strong research profiles in psychiatric, cancer, reproductive, pediatric, pharmaco, genetic, and geriatric epidemiology, eating disorders, precision medicine, and biostatistics.

Part of the success of our department is due to our collaborative spirit where one factor is that researchers at the Department share and co-finance common resources (e.g., IT and an applied biostatistics group). The department is situated at campus Solna. Further information can be found at http://ki.se/en/meb

The research group

The research group of aging epidemiology is involved in a wide variety of research projects, including molecular and genetic epidemiology, pharmacoepidemiology, as well as twin and family studies. The group contains about 20 people – from professor to PhD- and master students – with several different PI´s collaborating on many research topics within aging. Research interests are biological aging, frailty, genetics of dementia, polypharmacy in the old and many more.

The doctoral student project and the duties of the doctoral student

In this PhD project, we will investigate the relationship between epigenetic age and diabetes. We will also examine how medications affect epigenetic age differently among individuals with and without diabetes. Finally, we will utilize proteomics, epigenetics, and genetic data from various cohorts to predict diabetes risk. We will create organ-specific aging clocks using data from the SATSA, TwinGene, and SIMPLER cohorts. These studies aim to deepen our understanding of the complex relationship between biological aging and the risk of type 2 diabetes, offering insights that could potentially inform preventive strategies and personalized interventions for this widespread chronic disease.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirementYou meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Requirements:

• The applicant must have completed relevant education, preferably medical school, and have a strong interest in aging.
• The applicant should have research experience.
• The applicant should have some knowledge or training in aging biology, pharmacology, modeling, epigenetics, genetics, and metagenomics.
• The applicant should be familiar with handling large-scale data.
• The applicant must be fluent in English, both spoken and written.
• The applicant should be able to work well both in a team and independently, as well as in an international environment.

Preferred:

• Programming skills in R and Python are considered a strong asset.
• Familiarity with literature search, review, and summary of scientific articles.
• Knowledge of research in biological aging and epigenetics. Familiar with methods for measuring aging.
• A strong interest in data-driven research and interdisciplinary science, including bioinformatics, systems biology, machine learning, or biostatistics, with a focus on practical applications and problem-solving. 

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.